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The SLC26A9 inhibitor S9‐A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion

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Jo, Sungwoo ; Centeio, Raquel ; Park, Jinhong ; Ousingsawat, Jiraporn ; Jeon, Dong‐kyu ; Talbi, Khaoula ; Schreiber, Rainer ; Ryu, Kunhi ; Kahlenberg, Kristin ; Somoza, Veronika ; Delpiano, Livia ; Gray, Michael A. ; Amaral, Margarida D. ; Railean, Violeta ; Beekman, Jeffrey M. ; Rodenburg, Lisa W. ; Namkung, Wan ; Kunzelmann, Karl
Date of publication of this fulltext: 12 Oct 2022 04:48

This publication is part of the DEAL contract with Wiley.


The solute carrier 26 family member A9 (SLC26A9) is an epithelial anion transporter that is assumed to contribute to airway chloride secretion and surface hydration. Whether SLC26A9 or CFTR is responsible for airway Cl- transport under basal conditions is still unclear, due to the lack of a specific inhibitor for SLC26A9. In the present study, we report a novel potent and specific inhibitor for ...


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