Observation of conformational changes that underlie the catalytic cycle of Xrn2

URN to cite this document:: urn:nbn:de:bvb:355-epub-530379
DOI to cite this document:: 10.5283/epub.53037

Overbeck, Jan H. ; Stelzig, David

; Fuchs, Anna-Lisa ; Wurm, Jan Philip

; Sprangers, Remco

License: Creative Commons Attribution 4.0
PDF - Published Version
(7MB)

Date of publication of this fulltext: 24 Oct 2022 05:33

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Nuclear magnetic resonance (NMR) methods that quantitatively probe motions on molecular and atomic levels have propelled the understanding of biomolecular processes for which static structures cannot provide a satisfactory description. In this work, we studied the structure and dynamics of the essential 100-kDa eukaryotic 5′→3′ exoribonuclease Xrn2. A combination of complementary fluorine and ...