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Effect of the human endotoxin challenge on tedizolid tissue penetration

Jorda, Anselm ; Wulkersdorfer, Beatrix ; Schoergenhofer, Christian ; Matzneller, Peter ; Jalali, Valentin A. L. ; Bauer, Martin ; Wölfl‐Duchek, Michael ; Lackner, Edith ; Dorn, Christoph ; Jilma, Bernd ; Zeitlinger, Markus


The effects of the human endotoxin challenge on tissue pharmacokinetics are unknown. In the present study, we aimed to assess the effect of the endotoxin challenge on interstitial fluid pharmacokinetics of tedizolid in healthy volunteers using intramuscular microdialysis. Eight healthy male subjects were treated with 200 mg of tedizolid phosphate for 6 days. On day 6, an intravenous bolus of LPS ...


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