Successful Use of Interferon-Gamma for Refractory Disseminated Candida Tropicalis Infection in a Pediatric Patient with Acute Myeloid Leukemia and Heterozygous CARD9 Mutation

URN to cite this document:: urn:nbn:de:bvb:355-epub-530662
DOI to cite this document:: 10.5283/epub.53066

Kleinschmidt, Katharina ; Troeger, Anja ; Foell, Juergen ; Jakob, Marcus ; Corbacioglu, Selim

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Oct 2022 11:38

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Item type:	Article
Open Access Type:	Gold (with APC)
Journal or Publication Title:	Archives of Clinical and Medical Case Reports
Publisher:	Fortune Journals
Volume:	6
Number of Issue or Book Chapter:	5
Page Range:	pp. 626-629
Date:	16 September 2022
Institutions:	Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation
Keywords:	AML; Infections in Immunocompromised Hosts; Immunology; Immunotherapy; Molecular Genetics; Stem Cell Transplantation
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	53066

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Abstract

Invasive fungal infections remain among the most frequent severe and fatal complications of oncology, despite effective antifungal agents. Genetic aberrations may additionally increase the individual patient’s susceptibility to invasive mycosis, with the need for an intensified treatment, such as adjunctive immunotherapy combined with standard antifungal medication. Interferon-gamma (IFN-γ) as an ...