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Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain

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Blazquez, Raquel ; Chuang, Han-Ning ; Wenske, Britta ; Trigueros, Laura ; Wlochowitz, Darius ; Liguori, Renato ; Ferrazzi, Fulvia ; Regen, Tommy ; Proescholdt, Martin A. ; Rohde, Veit ; Riemenschneider, Markus J. ; Stadelmann, Christine ; Bleckmann, Annalen ; Beißbarth, Tim ; van Rossum, Denise ; Hanisch, Uwe K. ; Pukrop, Tobias
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Date of publication of this fulltext: 20 Oct 2022 05:37


Brain metastasis in breast cancer remains difficult to treat and its incidence is increasing. Therefore, the development of new therapies is of utmost clinical relevance. Recently, toll-like receptor (TLR) 4 was correlated with IL6 expression and poor prognosis in 1 215 breast cancer primaries. In contrast, we demonstrated that TLR4 stimulation reduces microglia-assisted breast cancer cell ...


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