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Distinct Mechanisms of IgM Antibody-Mediated Acquired von Willebrand Syndrome and Successful Treatment with Recombinant von Willebrand Factor in One Patient

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Höpting, Matthias ; Budde, Ulrich ; Tiede, Andreas ; Grube, Matthias ; Hahn, Joachim ; Herr, Wolfgang ; Heimerl, Susanne ; Hart, Christina
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 21 Oct 2022 06:23


Acquired von Willebrand Syndrome (AVWS) is a rare coagulation disorder which can be associated with IgM paraproteinaemia. Recently, recombinant von Willebrand factor (rVWF) has become available for the treatment of bleedings in patients with inherited von Willebrand disease, but experience in patients with AVWS is limited. We report on 2 patients with AVWS with underlying IgM paraproteinaemia ...


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