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Multivalent display of engineered HIV-1 envelope trimers on silica nanoparticles for targeting and in vitro activation of germline VRC01 B cells

Peterhoff, David ; Thalhauser, Stefanie ; Neckermann, Patrick ; Barbey, Clara ; Straub, Kristina ; Nazet, Julian ; Merkl, Rainer ; Längst, Gernot ; Breunig, Miriam ; Wagner, Ralf


Selective targeting of germline B cells with specifically designed germline-targeting HIV-1 envelope immunogens (GT-Env) is considered a feasible vaccination strategy to elicit broadly neutralizing antibodies (bnAbs). BnAbs are extremely valuable because they neutralize genetically distant viral strains at the same time. To overcome its inherently low affinity to germline B cells, the aim of the ...


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