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Multivalent display of engineered HIV-1 envelope trimers on silica nanoparticles for targeting and in vitro activation of germline VRC01 B cells
Peterhoff, David
, Thalhauser, Stefanie, Neckermann, Patrick , Barbey, Clara, Straub, Kristina, Nazet, Julian, Merkl, Rainer, Längst, Gernot, Breunig, Miriam and Wagner, Ralf
(2022)
Multivalent display of engineered HIV-1 envelope trimers on silica nanoparticles for targeting and in vitro activation of germline VRC01 B cells.
European Journal of Pharmaceutics and Biopharmaceutics 181, pp. 88-101.
Date of publication of this fulltext: 23 Nov 2022 14:56
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| Item type | Article | ||||||
| Journal or Publication Title | European Journal of Pharmaceutics and Biopharmaceutics | ||||||
| Publisher: | Elsevier | ||||||
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| Place of Publication: | AMSTERDAM | ||||||
| Volume: | 181 | ||||||
| Page Range: | pp. 88-101 | ||||||
| Date | 2022 | ||||||
| Institutions | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) | ||||||
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| Keywords | BROADLY NEUTRALIZING ANTIBODIES; ANTI-HIV-1 ANTIBODIES; RESPONSES; VACCINE; RECEPTORS; PROTEIN; DESIGN; STABILIZATION; IMMUNIZATION; DOMAIN; Nanotechnology; Silica nanoparticles; HIV-1; Vaccine; Immunogen design; Germline-targeting; Env; B cells; Multivalent interaction; Affinity; Avidity | ||||||
| Dewey Decimal Classification | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy 600 Technology > 615 Pharmacy | ||||||
| Status | Published | ||||||
| Refereed | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg | Yes | ||||||
| Item ID | 53245 |
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