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Semaphorin 3A-Neuropilin-1 Signaling Modulates MMP13 Expression in Human Osteoarthritic Chondrocytes

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Stöckl, Sabine ; Reichart, Johanna ; Zborilova, Magdalena ; Johnstone, Brian ; Grässel, Susanne
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Date of publication of this fulltext: 28 Nov 2022 09:54


Osteoarthritis (OA) is a complex disorder of diarthrodial joints caused by multiple risk factors and is characterized by articular cartilage destruction as well as changes in other articular tissues. Semaphorin 3A (Sema3A), known to be a chemo-repellent for sensory nerve fibers, has recently been implicated in cartilage OA pathophysiology. We demonstrated that the expression of SEMA3A and its ...


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