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Role of Fibroblast Growth Factors in the Crosstalk of Hepatic Stellate Cells and Uveal Melanoma Cells in the Liver Metastatic Niche

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Seitz, Tatjana ; John, Nora ; Sommer, Judith ; Dietrich, Peter ; Thasler, Wolfgang E. ; Hartmann, Arndt ; Evert, Katja ; Lang, Sven A. ; Bosserhoff, Anja ; Hellerbrand, Claus
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Date of publication of this fulltext: 02 Dec 2022 05:23


Hepatic metastasis is the critical factor determining tumor-associated mortality in different types of cancer. This is particularly true for uveal melanoma (UM), which almost exclusively metastasizes to the liver. Hepatic stellate cells (HSCs) are the precursors of tumor-associated fibroblasts and support the growth of metastases. However, the underlying mechanisms are widely unknown. Fibroblast ...


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