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CAR Triggered Release of Type-1 Interferon Limits CAR T-Cell Activities by an Artificial Negative Autocrine Loop

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Harrer, Dennis Christoph ; Schenkel, Charlotte ; Bezler, Valerie ; Kaljanac, Marcell ; Hartley, Jordan ; Barden, Markus ; Pan, Hong ; Holzinger, Astrid ; Herr, Wolfgang ; Abken, Hinrich
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 14 Dec 2022 13:09


The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory hematological malignancies. T cells redirected for universal cytokine-mediated killing (TRUCKs), commonly referred to as "fourth generation" CAR T-cells, are designed to release engineered payloads upon CAR-induced T-cell activation. Building on ...


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