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Increased zinc levels facilitate phenotypic detection of ceftazidime-avibactam resistance in metallo-β-lactamase-producing Gram-negative bacteria.

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Simon, Michaela ; Gerlach, Roman G ; Pfeifer, Yvonne ; Pfennigwerth, Niels ; Gatermann, Sören G ; Schröder, Agnes ; Hiergeist, Andreas ; Hamprecht, Axel ; Rügamer, Tamara ; Gessner, André ; Jantsch, Jonathan
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 14 Dec 2022 13:14


Ceftazidime-avibactam is one of the last resort antimicrobial agents for the treatment of carbapenem-resistant, Gram-negative bacteria. Metallo-beta-lactamase-producing bacteria are considered to be ceftazidime-avibactam resistant. Here, we evaluated a semi-automated antimicrobial susceptibility testing system regarding its capability to detect phenotypic ceftazidime-avibactam resistance in 176 ...


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