Additional Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) Improves Pre-Therapeutical Detection of Early-Stage (pT1a) Glottic Cancer: A Feasibility and Interobserver Reliability Study

URN to cite this document:

urn:nbn:de:bvb:355-epub-534544 Copy

DOI to cite this document:

10.5283/epub.53454 Copy

Schleder, Stephan ; May, Matthias ; Habicher, Werner ; Dinkel, Johannes ; Schreyer, Andreas G. ; Gostian, Antoniu-Oreste ; Schicho, Andreas

License: Creative Commons Attribution 4.0 PDF - Published Version (1MB)

Date of publication of this fulltext: 23 Dec 2022 08:10

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Details

Item type:	Article
Open Access Type:	Gold (without APC)
Journal or Publication Title:	Diagnostics
Publisher:	MDPI
Place of Publication:	BASEL
Volume:	12
Number of Issue or Book Chapter:	12
Page Range:	p. 3200
Date:	16 December 2022
Institutions:	Medicine > Lehrstuhl für Röntgendiagnostik
Identification Number:	Value Type 10.3390/diagnostics12123200 DOI
Keywords:	SQUAMOUS-CELL CARCINOMA; LARYNGEAL; HEAD; INVASION; NECK; CARTILAGE; ACCURACY; MRI; MRI; DWIBS; glottic cancer; staging
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	53454

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Abstract

(1) Background: Early-stage glottic cancer is easily missed on magnetic resonance imaging (MRI). Diffusion-weighted imaging (DWI) may improve diagnostic accuracy. Therefore, our aim was to assess the value of adding diffusion-weighted imaging with background body signal suppression (DWIBS) to pre-therapeutic MRI staging. (2) Methods: Two radiologists with 8 and 13 years of experience, blinded to ...

Abstract

(1) Background: Early-stage glottic cancer is easily missed on magnetic resonance imaging (MRI). Diffusion-weighted imaging (DWI) may improve diagnostic accuracy. Therefore, our aim was to assess the value of adding diffusion-weighted imaging with background body signal suppression (DWIBS) to pre-therapeutic MRI staging. (2) Methods: Two radiologists with 8 and 13 years of experience, blinded to each other's findings, initially interpreted only standard MRI, later DWIBS alone, and afterward, standard MRI + DWIBS in 41 patients with histopathologically proven pT1a laryngeal cancer of the glottis. (3) Results: Detectability rates with standard MRI, DWIBS only, and standard MRI + DWIBS were 68-71%, 63-66%, and 73-76%, respectively. Moreover, interobserver reliability was calculated as good (kappa = 0.712), very good (kappa = 0.84), and good (kappa = 0.69) for standard MRI, DWIBS only, and standard MRI + DWIBS, respectively. (4) Conclusions: Standard MRI, DWIBS alone, and standard MRI + DWIBS showed an encouraging detection rate, as well as distinct interobserver reliability in the diagnosis of early-stage laryngeal cancer when compared to the definitive histopathologic report.

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Metadata last modified: 16 Jan 2023 15:24

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