Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis

URN to cite this document:: urn:nbn:de:bvb:355-epub-535025
DOI to cite this document:: 10.5283/epub.53502

Kinateder, Thomas

; Drexler, Lukas ; Straub, Kristina

; Merkl, Rainer

; Sterner, Reinhard

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 10 Jan 2023 08:27

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Abstract

The conservation of fold and chemistry of the enzymes associated with histidine biosynthesis suggests that this pathway evolved prior to the diversification of Bacteria, Archaea, and Eukaryotes. The only exception is the histidinol phosphate phosphatase (HolPase). So far, non-homologous HolPases that possess distinct folds and belong to three different protein superfamilies have been identified ...