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TGFβ + small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro‐angiogenic phenotype

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Ludwig, Nils ; Yerneni, Saigopalakrishna S. ; Azambuja, Juliana H. ; Pietrowska, Monika ; Widłak, Piotr ; Hinck, Cynthia S. ; Głuszko, Alicja ; Szczepański, Mirosław J. ; Kärmer, Teresa ; Kallinger, Isabella ; Schulz, Daniela ; Bauer, Richard J. ; Spanier, Gerrit ; Spoerl, Steffen ; Meier, Johannes K. ; Ettl, Tobias ; Razzo, Beatrice M. ; Reichert, Torsten E. ; Hinck, Andrew P. ; Whiteside, Theresa L.
Date of publication of this fulltext: 09 Jan 2023 14:15


Transforming growth factor beta (TGF beta) is a major component of tumor-derived small extracellular vesicles (TEX) in cancer patients. Mechanisms utilized by TGF beta(+) TEX to promote tumor growth and pro-tumor activities in the tumor microenvironment (TME) are largely unknown. TEX produced by head and neck squamous cell carcinoma (HNSCC) cell lines carried TGF beta and angiogenesis-promoting ...


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