HDAC1-mediated regulation of GABA signaling within the lateral septum facilitates long-lasting social fear extinction in male mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-535558
DOI to cite this document:: 10.5283/epub.53555

Bludau, Anna

; Neumann, Inga D.

; Menon, Rohit

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Jan 2023 09:29

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Abstract

Social anxiety disorder (SAD) is caused by traumatic social experiences. It is characterized by intense fear and avoidance of social contexts, which can be robustly mimicked by the social fear conditioning (SFC) paradigm. The extinction phase of the SFC paradigm is akin to exposure therapy for SAD and requires learning to disassociate the trauma with the social context. Learning-induced ...