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TIGIT Expression on Intratumoral Lymphocytes Correlates with Improved Prognosis in Oral Squamous Cell Carcinoma

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Eichberger, Jonas ; Spoerl, Silvia ; Spanier, Gerrit ; Erber, Ramona ; Taxis, Juergen ; Schuderer, Johannes ; Ludwig, Nils ; Fiedler, Mathias ; Nieberle, Felix ; Ettl, Tobias ; Geppert, Carol I. ; Reichert, Torsten E. ; Spoerl, Steffen
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Jan 2023 05:51


(1) Background: T-cell immunoglobulin and ITIM domain (TIGIT) is a potential immunotherapeutic target in a variety of malignant entities, and antibody-based treatments are currently under investigation in clinical trials. While promising results were observed in patients with lung cancer, the role of TIGIT in oral squamous cell carcinoma (OSCC) as a biomarker as well as a therapeutic target ...


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