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CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea

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Hegner, Philipp ; Lebek, Simon ; Schaner, Benedikt ; Ofner, Florian ; Gugg, Mathias ; Maier, Lars Siegfried ; Arzt, Michael ; Wagner, Stefan
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Feb 2023 06:47


Left ventricular contractile dysfunction and arrhythmias frequently occur in patients with sleep-disordered breathing (SDB). The CaMKII-dependent dysregulation of cellular Ca homeostasis has recently been described in SDB patients, but these studies only partly explain the mechanism and are limited by the patients’ heterogeneity. Here, we analyzed contractile function and Ca homeostasis in a ...


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