CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea

URN to cite this document:: urn:nbn:de:bvb:355-epub-536629
DOI to cite this document:: 10.5283/epub.53662

Hegner, Philipp

; Lebek, Simon

; Schaner, Benedikt ; Ofner, Florian ; Gugg, Mathias ; Maier, Lars Siegfried

; Arzt, Michael

; Wagner, Stefan

License: Creative Commons Attribution 4.0
PDF - Published Version
(2MB)

Date of publication of this fulltext: 02 Feb 2023 06:47

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Left ventricular contractile dysfunction and arrhythmias frequently occur in patients with sleep-disordered breathing (SDB). The CaMKII-dependent dysregulation of cellular Ca homeostasis has recently been described in SDB patients, but these studies only partly explain the mechanism and are limited by the patients’ heterogeneity. Here, we analyzed contractile function and Ca homeostasis in a ...