Expression and Function of BMP and Activin Membrane-Bound Inhibitor (BAMBI) in Chronic Liver Diseases and Hepatocellular Carcinoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-537358
DOI to cite this document:: 10.5283/epub.53735

Weber, Florian

; Treeck, Oliver ; Mester, Patricia ; Buechler, Christa

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Feb 2023 17:38

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Abstract

BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) is a transmembrane pseudoreceptor structurally related to transforming growth factor (TGF)-β type 1 receptors (TGF-β1Rs). BAMBI lacks a kinase domain and functions as a TGF-β1R antagonist. Essential processes such as cell differentiation and proliferation are regulated by TGF-β1R signaling. TGF-β is the best-studied ligand of ...