Phenotypic Characterization of Colorectal Liver Metastases: Capsule versus No Capsule and the Potential Role of Epithelial Mesenchymal Transition

URN to cite this document:: urn:nbn:de:bvb:355-epub-537369
DOI to cite this document:: 10.5283/epub.53736

Fleig, Claudia ; Evert, Katja

; Schlitt, Hans J.

; Fichtner-Feigl, Stefan ; Brunner, Stefan M.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Feb 2023 17:31

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Abstract

Background: Colorectal liver metastases (CRLM) can be encased in a fibrous capsule separating cancer from normal liver tissue, which correlates with increased patient survival. This study investigated the cellular and molecular components of capsule formation and the possible role of epithelial mesenchymal transition (EMT). Methods: From 222 patients with CRLM, 84 patients (37.8%) were ...