Expression of pH-Sensitive GPCRs in Peritoneal Carcinomatosis of Colorectal Cancer—First Results

URN to cite this document:: urn:nbn:de:bvb:355-epub-538993
DOI to cite this document:: 10.5283/epub.53899

von Breitenbuch, Philipp ; Kurz, Bernadett ; Wallner, Susanne ; Zeman, Florian ; Brochhausen, Christoph

; Schlitt, Hans-Jürgen ; Schreml, Stephan

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 06 Mar 2023 16:28

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Abstract

Solid tumors have an altered metabolism with a so-called inside-out pH gradient (decreased pHe < increased pHi). This also signals back to tumor cells via proton-sensitive ion channels or G protein-coupled receptors (pH-GPCRs) to alter migration and proliferation. Nothing, however, is known about the expression of pH-GPCRs in the rare form of peritoneal carcinomatosis. Paraffinembedded tissue ...