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Expression of pH-Sensitive GPCRs in Peritoneal Carcinomatosis of Colorectal Cancer—First Results

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von Breitenbuch, Philipp ; Kurz, Bernadett ; Wallner, Susanne ; Zeman, Florian ; Brochhausen, Christoph ; Schlitt, Hans-Jürgen ; Schreml, Stephan
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Date of publication of this fulltext: 06 Mar 2023 16:28


Solid tumors have an altered metabolism with a so-called inside-out pH gradient (decreased pHe < increased pHi). This also signals back to tumor cells via proton-sensitive ion channels or G protein-coupled receptors (pH-GPCRs) to alter migration and proliferation. Nothing, however, is known about the expression of pH-GPCRs in the rare form of peritoneal carcinomatosis. Paraffinembedded tissue ...


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