GPR4 in the pH ‐dependent migration of melanoma cells in the tumor microenvironment

URN to cite this document:: urn:nbn:de:bvb:355-epub-540172
DOI to cite this document:: 10.5283/epub.54017

Stolwijk, Judith Anthea ; Wallner, Susanne ; Heider, Judith ; Kurz, Bernadett ; Pütz, Lisa ; Michaelis, Stefanie ; Goricnik, Barbara ; Erl, Julia ; Frank, Linda ; Berneburg, Mark

; Haubner, Frank ; Wegener, Joachim ; Schreml, Stephan

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 06 Apr 2023 06:25

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Abstract

Due to its high metastatic potential, malignant melanoma is one of the deadliest skin cancers. In melanoma as well as in other cancers, acidification of the tumor microenvironment (=TME, inverse pH-gradient) is a well-known driver of tumor progression and metastasis. Membrane-bound receptors, such as the proton-sensitive GPCR (pH-GPCR) GPR4, are considered as potential initiators of the ...