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GPR4 in the pH ‐dependent migration of melanoma cells in the tumor microenvironment

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Stolwijk, Judith Anthea ; Wallner, Susanne ; Heider, Judith ; Kurz, Bernadett ; Pütz, Lisa ; Michaelis, Stefanie ; Goricnik, Barbara ; Erl, Julia ; Frank, Linda ; Berneburg, Mark ; Haubner, Frank ; Wegener, Joachim ; Schreml, Stephan
Date of publication of this fulltext: 06 Apr 2023 06:25

This publication is part of the DEAL contract with Wiley.


Due to its high metastatic potential, malignant melanoma is one of the deadliest skin cancers. In melanoma as well as in other cancers, acidification of the tumor microenvironment (=TME, inverse pH-gradient) is a well-known driver of tumor progression and metastasis. Membrane-bound receptors, such as the proton-sensitive GPCR (pH-GPCR) GPR4, are considered as potential initiators of the ...


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