ObjectivesTo investigate the clinical performance of chairside fabricated tooth-supported posterior single crowns from lithium disilicate ceramic.Materials and methodsThirty-four crowns (IPS e.max CAD, Ivoclar Vivadent, Schaan, Liechtenstein) were inserted between 2006 and 2007 and again evaluated after 15 years. Survival and success rates were calculated according to Kaplan-Meier, and the quality of the crowns was evaluated by using modified United States Public Health (USPHS) criteria.ResultsTwenty-two crowns were available for recall; six patients were defined as dropouts. The mean observation period was 15.2 years (+/- 0.2). Six failures occurred (1 technical/5 biological) resulting in a survival rate of 80.1%. The success rate was 64.2%. The roughness of the crowns increased (p = 0.021) and the majority of adhesive gaps were discolored (p = 0.001) in comparison to baseline. The color, tooth, and crown integrity remained stable over the follow-up period (p >= 0.317).ConclusionThe fabrication of tooth-supported lithium disilicate crowns using a chairside approach yielded acceptable long-term survival and success rates. Due to discoloration, the long-term use of dual-cure self-adhesive resin cements might result in unpleasing esthetic results.