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Multi‐Site Conformational Exchange in the Synthetic Neomycin‐Sensing Riboswitch Studied by 19 F NMR

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Overbeck, Jan H. ; Vögele, Jennifer ; Nussbaumer, Felix ; Duchardt‐Ferner, Elke ; Kreutz, Christoph ; Wöhnert, Jens ; Sprangers, Remco
Date of publication of this fulltext: 03 May 2023 13:05

This publication is part of the DEAL contract with Wiley.


The synthetic neomycin-sensing riboswitch interacts with its cognate ligand neomycin as well as with the related antibiotics ribostamycin and paromomycin. Binding of these aminoglycosides induces a very similar ground state structure in the RNA, however, only neomycin can efficiently repress translation initiation. The molecular origin of these differences has been traced back to differences in ...


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