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Empagliflozin increases kidney weight due to increased cell size in the proximal tubule S3 segment and the collecting duct

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Sinha, Frederick ; Federlein, Anna ; Biesold, Annika ; Schwarzfischer, Magdalena ; Krieger, Katharina ; Schweda, Frank ; Tauber, Philipp
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Date of publication of this fulltext: 09 May 2023 12:22


The inhibition of renal SGLT2 glucose reabsorption has proven its therapeutic efficacy in chronic kidney disease. SGLT2 inhibitors (SGLTi) have been intensively studied in rodent models to identify the mechanisms of SGLT2i-mediated nephroprotection. So far, the overwhelming effects from clinical trials, could only partially be reproduced in rodent models of renal injury. However, a commonly ...


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