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TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma

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Menevse, Ayse N. ; Ammer, Laura-Marie ; Vollmann-Zwerenz, Arabel ; Kupczyk, Marcell ; Lorenz, Julia ; Weidner, Lorraine ; Hussein, Abir ; Sax, Julian ; Mühlbauer, Jasmin ; Heuschneider, Nicole ; Rohrmus, Celine ; Mai, Laura S. ; Jachnik, Birgitt ; Stamova, Slava ; Volpin, Valentina ; Durst, Franziska C. ; Sorrentino, Antonio ; Xydia, Maria ; Milenkovic, Vladimir M. ; Bader, Stefanie ; Braun, Frank K. ; Wetzel, Christian H. ; Albert, Nathalie L. ; Tonn, Joerg-Christian ; Bartenstein, Peter ; Proescholdt, Martin ; Schmidt, Nils O. ; Linker, Ralf A. ; Riemenschneider, Markus J. ; Beckhove, Philipp ; Hau, Peter
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 11 May 2023 04:44


Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with malignancy and poor prognosis, but also with increased immune infiltration. Here, we studied the role of TSPO in the regulation of immune resistance of human GB cells. The role of TSPO in ...


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