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Gender-Specific Differences in Serum Sphingomyelin Species in Patients with Hepatitis C Virus Infection—Sphingomyelin Species Are Related to the Model of End-Stage Liver Disease (MELD) Score in Male Patients

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Peschel, Georg ; Weigand, Kilian ; Grimm, Jonathan ; Müller, Martina ; Krautbauer, Sabrina ; Höring, Marcus ; Liebisch, Gerhard ; Buechler, Christa
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 May 2023 04:48


Hepatitis C virus (HCV) replication depends on cellular sphingomyelin (SM), but serum SM composition in chronic HCV infection has been hardly analyzed. In this work, 18 SM species could be quantified in the serum of 178 patients with chronic HCV infection before therapy with direct-acting antivirals (DAAs) and 12 weeks later, when therapy was completed. Six SM species were higher in the serum of ...


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