Interleukin-1ß Attenuates Expression of Augmenter of Liver Regeneration (ALR) by Regulating HNF4α Independent of c-Jun

URN to cite this document:: urn:nbn:de:bvb:355-epub-542322
DOI to cite this document:: 10.5283/epub.54232

Nimphy, Jonas ; Ibrahim, Sara ; Dayoub, Rania

; Kubitza, Marion ; Melter, Michael

; Weiss, Thomas S.

License: Creative Commons Attribution 4.0
PDF - Published Version
(2MB)

Date of publication of this fulltext: 16 May 2023 10:09

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Inflammasomes and innate immune cells have been shown to contribute to liver injury, thereby activating Kupffer cells, which release several cytokines, including IL-6, IL-1ß, and TNFα. Augmenter of liver regeneration (ALR) is a hepatotropic co-mitogen that was found to have anti-oxidative and anti-apoptotic properties and to attenuate experimental non-alcoholic fatty liver disease (NAFLD) and ...