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Interleukin-1ß Attenuates Expression of Augmenter of Liver Regeneration (ALR) by Regulating HNF4α Independent of c-Jun

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Nimphy, Jonas ; Ibrahim, Sara ; Dayoub, Rania ; Kubitza, Marion ; Melter, Michael ; Weiss, Thomas S.
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Date of publication of this fulltext: 16 May 2023 10:09


Inflammasomes and innate immune cells have been shown to contribute to liver injury, thereby activating Kupffer cells, which release several cytokines, including IL-6, IL-1ß, and TNFα. Augmenter of liver regeneration (ALR) is a hepatotropic co-mitogen that was found to have anti-oxidative and anti-apoptotic properties and to attenuate experimental non-alcoholic fatty liver disease (NAFLD) and ...


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