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Immune Checkpoint Profiling in Humanized Breast Cancer Mice Revealed Cell-Specific LAG-3/PD-1/TIM-3 Co-Expression and Elevated PD-1/TIM-3 Secretion

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Bruss, Christina ; Kellner, Kerstin ; Albert, Veruschka ; Hutchinson, James A. ; Seitz, Stephan ; Ortmann, Olaf ; Brockhoff, Gero ; Wege, Anja K.
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 May 2023 05:57


Checkpoint blockade is particularly based on PD-1/PD-L1-inhibiting antibodies. However, an efficient immunological tumor defense can be blocked not only by PD-(L)1 but also by the presence of additional immune checkpoint molecules. Here, we investigated the co-expression of several immune checkpoint proteins and the soluble forms thereof (e.g., PD-1, TIM-3, LAG-3, PD-L1, PD-L2 and others) in ...


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