18F-FDG PET/CT-derived total lesion glycolysis predicts abscess formation in patients with surgically confirmed infective endocarditis: Results of a retrospective study at a tertiary center

URN to cite this document:

urn:nbn:de:bvb:355-epub-543386 Copy

DOI to cite this document:

10.5283/epub.54338 Copy

Sag, Sabine Julia Maria ; Menhart, Karin ; Hitzenbichler, Florian ; Schmid, Christof ; Hofheinz, Frank ; van den Hoff, Jörg ; Maier, Lars Siegfried ; Hellwig, Dirk ; Grosse, Jirka ; Sag, Can Martin

License: Creative Commons Attribution 4.0 PDF - Published Version (3MB)

Date of publication of this fulltext: 06 Jun 2023 09:46

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This publication is part of the DEAL contract with Springer.

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Details

Item type:	Article
Open Access Type:	DEAL (Springer)
Journal or Publication Title:	Journal of Nuclear Cardiology
Publisher:	Springer
Date:	1 June 2023
Institutions:	Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Abteilung für Nuklearmedizin
Identification Number:	Value Type 10.1007/s12350-023-03285-5 DOI
Keywords:	18F-FDG PET/CT - infective endocarditis - total lesion glycolysis - valve abscess
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	54338

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Abstract

Background Abnormal activity of 18F-FDG PET/CT is a major Duke criterion in the diagnostic work-up of infective prosthetic valve endocarditis (IE). We hypothesized that quantitative lesion assessment by 18F-FDG PET/CT-derived standard maximum uptake ratio (SURmax), metabolic volume (MV), and total lesion glycolysis (TLG) might be useful in distinct subgroups of IE patients (e.g. IE-related ...

Abstract

Background
Abnormal activity of 18F-FDG PET/CT is a major Duke criterion in the diagnostic work-up of infective prosthetic valve endocarditis (IE). We hypothesized that quantitative lesion assessment by 18F-FDG PET/CT-derived standard maximum uptake ratio (SURmax), metabolic volume (MV), and total lesion glycolysis (TLG) might be useful in distinct subgroups of IE patients (e.g. IE-related abscess formation).
Methods
All patients (n = 27) hospitalized in our tertiary IE referral medical center from January 2014 to October 2018 with preoperatively performed 18F-FDG PET/CT and surgically confirmed IE were included into this retrospective analysis.
Results
Patients with surgically confirmed abscess formation (n = 10) had significantly increased MV (by ~ fivefold) and TLG (by ~ sevenfold) as compared to patients without abscess (n = 17). Receiver operation characteristics (ROC) analyses demonstrated that TLG (calculated as MV × SURmean, i.e. TLG (SUR)) had the most favorable area under the ROC curve (0.841 [CI 0.659 to 1.000]) in predicting IE-related abscess formation. This resulted in a sensitivity of 80% and a specificity of 88% at a cut-off value of 14.14 mL for TLG (SUR).
Conclusion
We suggest that 18F-FDG PET/CT-derived quantitative assessment of TLG (SUR) may provide a novel diagnostic tool in predicting endocarditis-associated abscess formation.

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Metadata last modified: 29 Jul 2024 10:27

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