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Scaffold-Based (Matrigel™) 3D Culture Technique of Glioblastoma Recovers a Patient-like Immunosuppressive Phenotype

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Braun, Frank K. ; Rothhammer-Hampl, Tanja ; Lorenz, Julia ; Pohl, Sandra ; Menevse, Ayse-Nur ; Vollmann-Zwerenz, Arabel ; Bumes, Elisabeth ; Büttner, Maren ; Zoubaa, Saida ; Proescholdt, Martin ; Schmidt, Nils O. ; Hau, Peter ; Beckhove, Philipp ; Winner, Beate ; Riemenschneider, Markus J.
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Jul 2023 07:53


Conventional 2D cultures are commonly used in cancer research though they come with limitations such as the lack of microenvironment or reduced cell heterogeneity. In this study, we investigated in what respect a scaffold-based (Matrigel™) 3D culture technique can ameliorate the limitations of 2D cultures. NGS-based bulk and single-cell sequencing of matched pairs of 2D and 3D models showed an ...


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