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Ex vivo expansion of lung cancer‐derived disseminated cancer cells from lymph nodes identifies cells associated with metastatic progression

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Treitschke, Steffi ; Weidele, Kathrin ; Varadarajan, Adithi Ravikumar ; Feliciello, Giancarlo ; Warfsmann, Jens ; Vorbeck, Sybille ; Polzer, Bernhard ; Botteron, Catherine ; Hoffmann, Martin ; Dechand, Vadim ; Mederer, Tobias ; Weber, Florian ; Werner‐Klein, Melanie ; Robold, Tobias ; Hofmann, Hans‐Stefan ; Werno, Christian ; Klein, Christoph A.
Date of publication of this fulltext: 17 Aug 2023 06:04

This publication is part of the DEAL contract with Wiley.


The cellular basis of the apparent aggressiveness in lung cancer is poorly understood but likely associated with functional or molecular features of disseminated cancer cells (DCCs). DCCs from epithelial cancers are mostly detected by antibodies directed against histogenetic markers such as cytokeratin or EpCAM. It has been argued that marker-negative metastatic founder cells might escape ...


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