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Feasibility of peripheral blood stem cell collection from sickle cell trait donors with an intensified G‐CSF regimen

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Mohrez, Morad ; Troeger, Anja ; Kleinschmidt, Katharina ; Hanafee Alali, Tarek ; Jakob, Marcus ; Brosig, Andreas Michael ; Hähnel, Viola ; Kietz, Silke ; Offner, Robert ; Burkhardt, Ralph ; Corbacioglu, Selim ; Ahrens, Norbert ; Foell, Juergen
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Date of publication of this fulltext: 29 Aug 2023 05:49

This publication is part of the DEAL contract with Wiley.


Objectives Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for SCD and bone marrow from an HLA-matched sibling is currently the standard of care. Haploidentical HSCT from a family donor with a TCR αβ/CD19 depleted graft (T-haplo) is an increasingly successful alternative, which requires the generation of G-CSF stimulated peripheral stem cell (PBSC) from ...


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