A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza

URN to cite this document:: urn:nbn:de:bvb:355-epub-547892
DOI to cite this document:: 10.5283/epub.54789

Rappe, Julie C.F. ; Finsterbusch, Katja ; Crotta, Stefania ; Mack, Matthias ; Priestnall, Simon L. ; Wack, Andreas

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Oct 2023 10:51

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Abstract

Cytokine-mediated immune-cell recruitment and inflammation contribute to protection in respiratory virus infection. However, uncontrolled inflammation and the "cytokine storm" are hallmarks of immunopathology in severe infection. Cytokine storm is a broad term for a phenomenon with diverse characteristics and drivers, depending on host genetics, age, and other factors. Taking advantage of the ...