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Development of Photoswitchable Tethered Ligands that Target the µ-Opioid Receptor

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Lahmy, Ranit ; König, Burkhard ; Huebner, Harald ; Lachmann, Daniel ; Gmeiner, Peter
Date of publication of this fulltext: 18 Oct 2023 05:53

This publication is part of the DEAL contract with Wiley.


Converting known ligands into photoswitchable derivatives offers the opportunity to modulate compound structure with light and hence, biological activity. In doing so, these probes provide unique control when evaluating G-protein-coupled receptor (GPCR) mechanism and function. Further conversion of such compounds into covalent probes, known as photoswitchable tethered ligands (PTLs), offers ...


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