Development of Photoswitchable Tethered Ligands that Target the µ-Opioid Receptor

URN to cite this document:: urn:nbn:de:bvb:355-epub-548416
DOI to cite this document:: 10.5283/epub.54841

Lahmy, Ranit ; König, Burkhard

; Huebner, Harald ; Lachmann, Daniel ; Gmeiner, Peter

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Oct 2023 05:53

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Abstract

Converting known ligands into photoswitchable derivatives offers the opportunity to modulate compound structure with light and hence, biological activity. In doing so, these probes provide unique control when evaluating G-protein-coupled receptor (GPCR) mechanism and function. Further conversion of such compounds into covalent probes, known as photoswitchable tethered ligands (PTLs), offers ...