Can Exercise Enhance the Efficacy of Checkpoint Inhibition by Modulating Anti-Tumor Immunity?

URN to cite this document:: urn:nbn:de:bvb:355-epub-548837
DOI to cite this document:: 10.5283/epub.54883

Brummer, Christina ; Pukrop, Tobias

; Wiskemann, Joachim ; Bruss, Christina ; Ugele, Ines ; Renner, Kathrin

License: Creative Commons Attribution 4.0
PDF - Published Version
(2MB)

Date of publication of this fulltext: 20 Oct 2023 12:30

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Immune checkpoint inhibition (ICI) has revolutionized cancer therapy. However, response to ICI is often limited to selected subsets of patients or not durable. Tumors that are non-responsive to checkpoint inhibition are characterized by low anti-tumoral immune cell infiltration and a highly immunosuppressive tumor microenvironment. Exercise is known to promote immune cell circulation and improve ...