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Can Exercise Enhance the Efficacy of Checkpoint Inhibition by Modulating Anti-Tumor Immunity?

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Brummer, Christina ; Pukrop, Tobias ; Wiskemann, Joachim ; Bruss, Christina ; Ugele, Ines ; Renner, Kathrin
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Oct 2023 12:30


Immune checkpoint inhibition (ICI) has revolutionized cancer therapy. However, response to ICI is often limited to selected subsets of patients or not durable. Tumors that are non-responsive to checkpoint inhibition are characterized by low anti-tumoral immune cell infiltration and a highly immunosuppressive tumor microenvironment. Exercise is known to promote immune cell circulation and improve ...


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