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The microbial metabolite desaminotyrosine enhances T-cell priming and cancer immunotherapy with immune checkpoint inhibitors

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Joachim, Laura ; Göttert, Sascha ; Sax, Anna ; Steiger, Katja ; Neuhaus, Klaus ; Heinrich, Paul ; Fan, Kaiji ; Orberg, Erik Thiele ; Kleigrewe, Karin ; Ruland, Jürgen ; Bassermann, Florian ; Herr, Wolfgang ; Posch, Christian ; Heidegger, Simon ; Poeck, Hendrik
Date of publication of this fulltext: 24 Oct 2023 14:52


Background Inter-individual differences in response to immune checkpoint inhibitors (ICI) remain a major challenge in cancer treatment. The composition of the gut microbiome has been associated with differential ICI outcome, but the underlying molecular mechanisms remain unclear, and therapeutic modulation challenging. Methods We established an in vivo model to treat C57Bl/6j mice with the ...


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