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Photoswitchable Probes of Oxytocin and Vasopressin

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Wirth, Ulrike ; Raabe, Konstantin ; Kalaba, Predrag ; Keimpema, Erik ; Muttenthaler, Markus ; König, Burkhard
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Date of publication of this fulltext: 26 Oct 2023 04:19


Oxytocin (OT) and vasopressin (VP) are related neuropeptides that regulate many biological processes. In humans, OT and VP act via four G protein-coupled receptors, OTR, V1aR, V1bR, and V2R (VPRs), which are associated with several disorders. To investigate the therapeutic potential of these receptors, particularly in the receptor-dense areas of the brain, molecular probes with a high temporal ...


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