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Simultaneous Inhibition of Mcl-1 and Bcl-2 Induces Synergistic Cell Death in Hepatocellular Carcinoma

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Michalski, Marlen ; Bauer, Magdalena ; Walz, Franziska ; Tümen, Deniz ; Heumann, Philipp ; Stöckert, Petra Diana ; Gunckel, Manuela ; Kunst, Claudia ; Kandulski, Arne ; Schmid, Stephan ; Müller, Martina ; Gülow, Karsten
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Date of publication of this fulltext: 25 Oct 2023 12:11


Despite the recent approval of new therapies, the prognosis for patients with hepatocellular carcinoma (HCC) remains poor. There is a clinical need for new highly effective therapeutic options. Here, we present a combined application of BH3-mimetics as a potential new treatment option for HCC. BH3-mimetics inhibit anti-apoptotic proteins of the BCL-2 family and, thus, trigger the intrinsic ...


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