The p53 Family of Transcription Factors Represses the Alpha- fetoprotein Gene Expression in Hepatocellular Carcinoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-549519
DOI to cite this document:: 10.5283/epub.54951

Kunst, Claudia ; Gülow, Karsten ; Müller, Martina ; Schlosser, Sophie

; Schmid, Stephan

; Heumann, Philipp ; Tümen, Deniz ; Staub, Agnes ; Ostheim, Elisabeth ; Wölfel, Gisela

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 02 Nov 2023 14:28

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Abstract

Background: p53 deletion and mutation as well as upregulation of alpha-fetoprotein (AFP) are hallmarks of hepatocarcinogenesis. p63 and p73 belong to the family of p53-related transcription factors expressing a variety of isoforms. The expression of dominant negative (Delta N) p73 is related to the reduced survival of patients with hepatocellular carcinoma (HCC). In this study, we characterized ...