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TGFβ carrying exosomes in plasma: potential biomarkers of cancer progression in patients with head and neck squamous cell carcinoma

Ludwig, Nils ; Yerneni, Saigopalakrishna S. ; Harasymczuk, Malgorzata ; Szczepański, Mirosław J. ; Głuszko, Alicja ; Kukwa, Wojciech ; Jordan, Theresa ; Spanier, Gerrit ; Taxis, Juergen ; Spoerl, Steffen ; Meier, Johannes K. ; Hinck, Cynthia S. ; Campbell, Phil G. ; Reichert, Torsten E. ; Hinck, Andrew P. ; Whiteside, Theresa L.




Abstract

ObjectivesContributions of TGF beta to cancer progression are well documented. However, plasma TGF beta levels often do not correlate with clinicopathological data. We examine the role of TGF beta carried in exosomes isolated from murine and human plasma as a contributor to disease progression in head and neck squamous cell carcinoma (HNSCC).Materials and methodsThe 4-nitroquinoline-1-oxide ...

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