Oxidative DNA damage in reconstituting T cells is associated with relapse and inferior survival after allo-SCT

DOI to cite this document:: 10.5283/epub.54993

Karl, F. ; Liang, C. ; Böttcher-Loschinski, R. ; Stoll, A.

; Flamann, C. ; Richter, S. ; Lischer, C.

; Völkl, S. ; Jacobs, B. ; Böttcher, M. ; Jitschin, R. ; Bruns, H. ; Fischer, T. ; Holler, E. ; Rösler, W. ; Dandekar, T. ; Mackensen, A. ; Mougiakakos, D.

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Date of publication of this fulltext: 14 Nov 2023 16:01

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Abstract

Allogeneic hematopoietic stem cell transplantation (allo-SCT) is the only curative treat-ment option for a number of hematologic malignancies. Its therapeutic potential relies on the potency of donor T cells to eliminate residual malignant cells, the so-called graft -versus-leukemia (GVL) effect. Disease relapse remains the most frequent treatment failure and is associated with poor outcome. ...