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Characterization of sncRNA7SL in neuroblastoma cell lines

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Weigert, Nina
Date of publication of this fulltext: 17 Nov 2023 05:58

Abstract (German)

The RNA-binding protein La plays a major role in the processing and maturation process of RNA polymerase III (Pol III) precursor transcripts, such as tRNA and the long non-coding RNA 7SL. Depletion of the La protein in cancer cells causes aberrant expression of small non-coding (snc) RNAs derived from RNA Pol III transcripts, as recently demonstrated for tRNA-derived miRNAs. Herein a sncRNA was ...


Translation of the abstract (German)

Das RNA-bindende Protein La spielt eine wichtige Rolle bei der Verarbeitung und Reifung von Vorläufertranskripten der RNA-Polymerase III (Pol III), wie z. B. tRNA und die lange nicht-kodierende RNA 7SL. Die Deletion des La-Proteins in Krebszellen führt zu einer abweichenden Expression von kleinen nicht-kodierenden (snc) RNAs, die von RNA Pol III-Transkripten abgeleitet sind, wie kürzlich für ...


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