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Staphylococcus aureus From an Acute Fracture-related Infection Displays Important Bacteriological and Histopathologic Differences From a Chronic Equivalent in a Murine Bone Infection Model

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Baertl, Susanne ; Gens, Lena ; Nehrbass, Dirk ; Sumrall, Eric T. ; Zeiter, Stephan ; Mannala, Gopala Krishna ; Rupp, Markus ; Walter, Nike ; Richards, R. Geoff ; Moriarty, T. Fintan ; Alt, Volker
Date of publication of this fulltext: 17 Nov 2023 15:34


Background Staphylococcus aureus is the leading pathogen in fracture-related infection. Previous in vitro experiments, in vivo testing in wax moth larvae, and genomic analysis of clinical S. aureus isolates from fracture-related infection identified low-virulence (Lo-SA5464) and high-virulence (Hi-SA5458) strains. These findings correlated with acute fracture-related infection induced by ...


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