Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract

URN to cite this document:: urn:nbn:de:bvb:355-epub-550596
DOI to cite this document:: 10.5283/epub.55059

Ousingsawat, Jiraporn

; Centeio, Raquel ; Schreiber, Rainer

; Kunzelmann, Karl

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Nov 2023 08:58

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Abstract

Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide and ivermectin, are intensively discussed for the treatment of viral inflammatory airway infections. Here, we examined these repurposed drugs with respect to their anti-inflammatory effects in airways in vivo and in ...