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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-551198
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.55119
Zusammenfassung
Cleidocranial dysplasia (CCD) is a rare genetic defect caused by a heterozygous mutation of runt-related transcription factor 2 (RUNX2), which is important for osteoblast and skeletal development. RUNX2-deficiency causes extra- and intra-oral malformations that often require orthodontic treatment. Nicotinamide (NAM) affects bone remodelling processes. As these are crucial for orthodontic therapy, ...
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