Impact of Mechanical Strain and Nicotinamide on RUNX2-Deficient Osteoblast Mimicking Cleidocranial Dysplasia

URN to cite this document:: urn:nbn:de:bvb:355-epub-551198
DOI to cite this document:: 10.5283/epub.55119

Schröder, Agnes

; Örs, Talia ; Byeon, Ye-Oun ; Cieplik, Fabian

; Proff, Peter

; Kirschneck, Christian

; Paddenberg, Eva

License: Creative Commons Attribution 4.0
PDF - Published Version
(1MB)

Date of publication of this fulltext: 27 Nov 2023 16:25

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Cleidocranial dysplasia (CCD) is a rare genetic defect caused by a heterozygous mutation of runt-related transcription factor 2 (RUNX2), which is important for osteoblast and skeletal development. RUNX2-deficiency causes extra- and intra-oral malformations that often require orthodontic treatment. Nicotinamide (NAM) affects bone remodelling processes. As these are crucial for orthodontic therapy, ...