Go to content
UR Home

Impact of Mechanical Strain and Nicotinamide on RUNX2-Deficient Osteoblast Mimicking Cleidocranial Dysplasia

URN to cite this document:
DOI to cite this document:
Schröder, Agnes ; Örs, Talia ; Byeon, Ye-Oun ; Cieplik, Fabian ; Proff, Peter ; Kirschneck, Christian ; Paddenberg, Eva
[img]License: Creative Commons Attribution 4.0
PDF - Published Version
Date of publication of this fulltext: 27 Nov 2023 16:25


Cleidocranial dysplasia (CCD) is a rare genetic defect caused by a heterozygous mutation of runt-related transcription factor 2 (RUNX2), which is important for osteoblast and skeletal development. RUNX2-deficiency causes extra- and intra-oral malformations that often require orthodontic treatment. Nicotinamide (NAM) affects bone remodelling processes. As these are crucial for orthodontic therapy, ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons