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Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex

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Breindl, Matthias ; Spitzer, Dominika ; Gerasimaitė, Rūta ; Kairys, Visvaldas ; Schubert, Thomas ; Henfling, Ramona ; Schwartz, Uwe ; Lukinavičius, Gražvydas ; Manelytė, Laura
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Date of publication of this fulltext: 05 Dec 2023 11:48


Baz2B is a regulatory subunit of the ATP-dependent chromatin remodeling complexes BRF1 and BRF5, which control access to DNA during DNA-templated processes. Baz2B has been implicated in several diseases and also in unhealthy ageing, however limited information is available on the domains and cellular roles of Baz2B. To gain more insight into the Baz2B function, we biochemically characterized the ...


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