Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges

URN to cite this document:: urn:nbn:de:bvb:355-epub-551663
DOI to cite this document:: 10.5283/epub.55166

Harrer, Dennis Christoph

; Li, Sin-Syue ; Kaljanac, Marcell ; Barden, Markus ; Pan, Hong ; Abken, Hinrich

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Dec 2023 13:56

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Abstract

Chimeric antigen receptor (CAR) T cells are "living drugs" that specifically recognize their target antigen through an antibody-derived binding domain resulting in T cell activation, expansion, and destruction of cognate target cells. The FDA/EMA approval of CAR T cells for the treatment of B cell malignancies established CAR T cell therapy as an emerging pillar of modern immunotherapy. However, ...