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Endogenous Sox8 is a critical factor for timely remyelination and oligodendroglial cell repletion in the cuprizone model

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Freudenstein, David ; Lippert, Magdalena ; Popp, Janina Sophie ; Aprato, Jessica ; Wegner, Michael ; Sock, Elisabeth ; Haase, Stefanie ; Linker, Ralf A. ; González Alvarado, María Nazareth
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Date of publication of this fulltext: 21 Dec 2023 07:14


Genome-wide association studies identified a single nucleotide polymorphism (SNP) downstream of the transcription factor Sox8, associated with an increased risk of multiple sclerosis (MS). Sox8 is known to influence oligodendrocyte terminal differentiation and is involved in myelin maintenance by mature oligodendrocytes. The possible link of a Sox8 related SNP and MS risk, along with the role of ...


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