Subtypes of Melanomas Associated with Different Degrees of Actinic Elastosis in Conventional Histology, Irrespective of Age and Body Site, Suggesting Chronic Ultraviolet Light Exposure as Driver for Lentigo Maligna Melanoma and Nodular Melanoma

URN to cite this document:

urn:nbn:de:bvb:355-epub-552723 Copy

DOI to cite this document:

10.5283/epub.55272 Copy

Drexler, Konstantin ; Zenderowski, Veronika ; Schreieder, Laura ; Koschitzki, Kevin ; Karrer, Sigrid ; Berneburg, Mark ; Haferkamp, Sebastian ; Niebel, Dennis

License: Creative Commons Attribution 4.0 PDF - Published Version (3MB)

Date of publication of this fulltext: 22 Dec 2023 08:41

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	3279.84
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	Cancers
Publisher:	MDPI
Volume:	16
Number of Issue or Book Chapter:	1
Page Range:	p. 1
Date:	19 December 2023
Institutions:	Medicine > Lehrstuhl für Dermatologie und Venerologie
Identification Number:	Value Type 10.3390/cancers16010001 DOI
Keywords:	actinic elastosis; melanoma; nevogenesis; carcinogenesis; histopathology
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	55272

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Abstract

(1) Background: Ultraviolet (UV) radiation and sunburns are associated with an increased incidence of acquired nevi and melanomas. However, the data are controversial as to whether chronic UV exposure or high intermittent UV exposure is the major carcinogenic factor in melanocytic tumors. In this study, we compared the degree of actinic elastosis (AE) as a surrogate for lifetime UV ...

Abstract

(1) Background: Ultraviolet (UV) radiation and sunburns are associated with an increased
incidence of acquired nevi and melanomas. However, the data are controversial as to whether chronic
UV exposure or high intermittent UV exposure is the major carcinogenic factor in melanocytic tumors.
In this study, we compared the degree of actinic elastosis (AE) as a surrogate for lifetime UV exposure
in nevi and different clinical melanoma subtypes (i.e., superficial spreading melanoma (SSM), nodular
malignant melanoma (NMM), acral lentiginous melanoma (ALM), and lentigo maligna melanoma
(LMM)) with respect to clinical variables (age, sex, and body site). (2) Methods: We defined a
semi-quantitative score for the degree of AE ranging from 0 = none to 3 = total loss of elastic fibers
(basophilic degeneration) and multiplied it by the perilesional vertical extent (depth), measured
histometrically (tumor-associated elastosis grade (TEG)).We matched the TEG of n = 595 melanocytic
lesions from 559 patients with their clinical variables. (3) Results: The TEG was correlated with age
and UV-exposed body sites. Furthermore, the TEG was significantly higher in LMM than in all other
types of melanomas and the TEG in NMM was higher than in SSM, irrespective of patient age and
tumor site. (4) Conclusions: High cumulative UV exposure is more strongly associated with LMM
and NMM than with other melanoma subtypes.

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Metadata last modified: 05 Jul 2024 15:35

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