Using the previously introduced modified discrete dipole approximation (DDA) method by applying the full details of the nanoparticle and its surrounding environment, the detection sensitivity of molecules by plasmonic Rod-based nanosensors, including U-shaped and Rod-shaped structures, was investigated. In the calculations, the two factors of the magnitude of the wavelength shift and the ability to distinguish molecules with similar properties were of significant interest. The results indicated that the sensitivity of Rod-based nanostructures is significantly higher than that of spherical nanoparticles. Among the plasmonic Rod-based nanosensors, the silver U-shaped structure performs better than others. The wavelength shift of the absorption spectrum of different nanosensors for a given molecule was very different, making it possible to detect very similar molecules from each other by testing different sensors.